Erythropoiesis defect observed in STAT3 GOF patients with severe anemia
نویسندگان
چکیده
منابع مشابه
Diamond-Blackfan anemia: a congenital defect in erythropoiesis.
Diamond-Blackfan anemia (DBA) is a congenital pure red blood cell aplasia diagnosed in the first year of life. Familiarity is apparent in 10% of patients, with all other cases being sporadic. Physical abnormalities are present in at least one third of patients, pointing to a defect in early embryo development. The main clinical sign is profound isolated anemia, with normal numbers and functioni...
متن کاملErythropoiesis in Fanconi's anemia.
Fanconi's anemia (FA) is an autosomal recessive condition in which greater than 90% of the homozygotes develop aplastic anemia. To determine the relation between erythroid progenitors and clinical status, blood and marrow mononuclear cells were cultured in methyl cellulose with erythropoietin, plus other hematopoietic growth factors, and growth in normal oxygen (20%) was compared with growth in...
متن کاملAnemia in Patients with Phenylketonuria in Yazd
Abstract Background Phenyl ketonuria (PKU) is a congenital metabolic disease. Irreversible brain damage is the result of phenyl alanin accumulation, so its amount should be restricted in patients diet. In their diet, trace elements such as hem Iron, folic acid, vitamin B12 and, etc are also limited, and could represent anemia. In this study, the frequency of anemia in PKU patients in Yazd wa...
متن کاملAnemia and Erythropoiesis in Cancer
Approximately one third to one half of patients with cancer are anemic, a condition that diminishes the ability to engage in daily activities and undermines the overall quality of life. Although cancer-related anemia has many causes, one of the most important is inadequate production and impaired utilization of erythropoietin. At any given level of anemia, patients with cancer produce much less...
متن کاملAnemia of Aging: A Model of Erythropoiesis in Cancer Patients.
The adverse effects of anemia in cancer patients include fatigue and enhanced chemotherapy-related toxicity. Anemia is particularly threatening for the older person with cancer who can have multiple comorbid conditions that may either cause anemia or aggravate the effects of anemia on other tissues.3 Because the functional reserve of different organ systems becomes progressively restricted with...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Allergy and Clinical Immunology
سال: 2020
ISSN: 0091-6749
DOI: 10.1016/j.jaci.2019.11.042